One of the main etiological agents of periodontal diseases are periodontal bacteria and the response that each individual produces to this infection will depend on genetic factors and those found in the environment that surrounds them. The objectives of periodontal therapies are the elimination of a large number of bacteria and their degradation products to allow the short-term resolution of the established pathology and the control of periodontal infection. The responsibility of microorganisms in the initiation and progression of gingival and periodontal diseases has been demonstrated in several studies.Currently, there are several therapeutic methodologies that can be used individually or in combination to achieve change in the bacterial ecosystem and thus allow resolution of the pathology.The present study evaluated the efficacy of a novel protocol combining non-surgical periodontal therapy with Piezosurgery (woodpecker bone piezosurgery) with systemic administration of specific antibiotics. Clinical and microscopic evaluations were recorded. The treatment protocol demonstrated rapid resolution of the pathology with good stability in subsequent evaluations and rapid recuperation of gingival tissues.