Speakers - 2026

Title: Platelet-rich fibrin (prf) in oral surgery: Advancing healing and regeneration

Abstract

Introduction: Platelet-rich fibrin (PRF), a second-generation platelet concentrate, has emerged as a promising adjunct in oral and maxillofacial surgery. By harnessing autologous growth factors and cytokines, PRF accelerates tissue healing, reduces postoperative complications, and promotes bone regeneration. Despite its increasing clinical use, comprehensive data on its outcomes across different oral surgical procedures is still evolving.

Methods: We performed a review of clinical and translational studies from 2013–2025, focusing on PRF applications in third molar surgery, implant placement, alveolar ridge preservation, and management of osteonecrosis. Outcomes evaluated included healing time, infection rates, pain scores, and radiographic evidence of bone regeneration.

Results: Findings consistently demonstrate that PRF reduces postoperative pain and swelling, enhances soft tissue closure, and accelerates bone healing. In implant surgery, PRF improved osseointegration and marginal bone stability. In third molar extractions, patients treated with PRF reported lower pain scores and faster recovery. Its application in osteonecrosis cases showed promising regenerative potential with reduced recurrence rates.

Conclusion: PRF is a simple, cost-effective, and biologically safe adjunct that significantly improves healing outcomes in oral surgery. Its broad applications make it an invaluable tool in modern surgical practice. Future research should explore standardized preparation protocols and its long-term effects in complex reconstructive cases.